Ontology highlight
ABSTRACT:
SUBMITTER: Armakolas A
PROVIDER: S-EPMC6016866 | biostudies-other | 2018 Mar
REPOSITORIES: biostudies-other
Armakolas A A Dimakakos A A Loukogiannaki C C Armakolas N N Antonopoulos A A Florou C C Tsioli P P Papageorgiou E E Alexandrou T P TP Stathaki M M Spinos D D Pektasides D D Patsouris E E Koutsilieris M M
Molecular medicine (Cambridge, Mass.) 20180315 1
<h4>Background</h4>Ec peptide (PEc), resulting from the proteolytic cleavage of the IGF-1Ec isoform, is involved in prostate cancer progression and metastasis, whereas in muscle tissue, it is associated with the mobilization of satellite cells prior to repair. Our aim is to determine the physiological conditions associated to the IGF-1Ec upregulation and PEc secretion in prostate tumors, as well as, the effect of tumor PEc on tumor repair.<h4>Methods</h4>IGF-1 (mature and isoforms) expression wa ...[more]