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Antioxidant and Anti-Osteoporosis Activities of Chemical Constituents of the Stems of Zanthoxylum piperitum.


ABSTRACT: Two new lignans, zanthoxyloside C (1) and zanthoxyloside D (2), together with nine known compounds comprising lignans (3-5), flavonoids (6-8), and phenolics (9-11), were isolated from the methanol extract of the stems of Zanthoxylum piperitum. All isolates were evaluated for their antioxidant and anti-osteoporotic activities using oxygen radical absorbance capacity (ORAC), cupric reducing antioxidant capacity (CUPRAC), and tartrate-resistant acid phosphatase (TRAP) assays. Compounds 7-10 showed peroxyl radical-scavenging capacities and 4, 6-7, and 9 showed reducing capacities. Moreover, compounds 3, 6-9, and 11 significantly suppressed TRAP activities. These results indicated that the stems of Z. piperitum could be an excellent source for natural antioxidant and anti-osteoporosis.

SUBMITTER: Yang SY 

PROVIDER: S-EPMC6017793 | biostudies-other | 2018 Feb

REPOSITORIES: biostudies-other

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Antioxidant and Anti-Osteoporosis Activities of Chemical Constituents of the Stems of Zanthoxylum piperitum.

Yang Seo Young SY   Lee Sang-Hyun SH   Tai Bui Huu BH   Jang Hae-Dong HD   Kim Young Ho YH  

Molecules (Basel, Switzerland) 20180218 2


Two new lignans, zanthoxyloside C (<b>1</b>) and zanthoxyloside D (<b>2</b>), together with nine known compounds comprising lignans (<b>3</b>-<b>5</b>), flavonoids (<b>6</b>-<b>8</b>), and phenolics (<b>9</b>-<b>11</b>), were isolated from the methanol extract of the stems of <i>Zanthoxylum piperitum.</i> All isolates were evaluated for their antioxidant and anti-osteoporotic activities using oxygen radical absorbance capacity (ORAC), cupric reducing antioxidant capacity (CUPRAC), and tartrate-r  ...[more]

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