Ontology highlight
ABSTRACT:
SUBMITTER: Zhu L
PROVIDER: S-EPMC6017886 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Molecules (Basel, Switzerland) 20180418 4
Amantadine (AMA) and its derivatives are illicit veterinary drugs that are hard to detect at very low concentrations. Developing a fast, simple and highly sensitive method for the detection of AMA is highly in demand. Here, we designed an anthracyclic compound (ABAM) that binds to a cucurbit[7]uril (CB[7]) host with a high association constant of up to 8.7 × 10⁸ M<sup>−1</sup>. The host-guest complex was then used as a fluorescent probe for the detection of AMA. Competition by AMA for occupying ...[more]