Ontology highlight
ABSTRACT:
SUBMITTER: Burgstaller JP
PROVIDER: S-EPMC6021422 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Burgstaller Joerg P JP Kolbe Thomas T Havlicek Vitezslav V Hembach Stephanie S Poulton Joanna J Piálek Jaroslav J Steinborn Ralf R Rülicke Thomas T Brem Gottfried G Jones Nick S NS Johnston Iain G IG
Nature communications 20180627 1
Vital mitochondrial DNA (mtDNA) populations exist in cells and may consist of heteroplasmic mixtures of mtDNA types. The evolution of these heteroplasmic populations through development, ageing, and generations is central to genetic diseases, but is poorly understood in mammals. Here we dissect these population dynamics using a dataset of unprecedented size and temporal span, comprising 1947 single-cell oocyte and 899 somatic measurements of heteroplasmy change throughout lifetimes and generatio ...[more]