Unknown

Dataset Information

0

Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral Sarcophyton stellatum.

ABSTRACT: Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A?C (1?3), stellatumonins A and B (4 and 5), and stellatumonone (6), were isolated together with ten known related compounds (7?16) from the ethyl acetate (EtOAc) extract of soft coral Sarcophyton stellatum. The structures of the new compounds were established by extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy and data comparison with related structures. Compounds 8 and 14 were isolated from a natural source for the first time. The isolated metabolites were shown to be not cytotoxic against a limited panel of cancer cells. Compound 9 showed anti-inflammatory activity by reducing the expression of proinflammatory cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) proteins in lipopolysaccharide (LPS)-stimulated mouse leukaemic monocyte macrophage (RAW 264.7) cells.

SUBMITTER: Ahmed AF 

PROVIDER: S-EPMC6025080 | biostudies-other | 2018 Jun

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral <i>Sarcophyton stellatum</i>.

Ahmed Atallah F AF   Chen Yi-Wei YW   Huang Chiung-Yao CY   Tseng Yen-Ju YJ   Lin Chi-Chen CC   Dai Chang-Feng CF   Wu Yang-Chang YC   Sheu Jyh-Horng JH  

Marine drugs 20180614 6

Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A⁻C (<b>1</b>⁻<b>3</b>), stellatumonins A and B (<b>4</b> and <b>5</b>), and stellatumonone (<b>6</b>), were isolated together with ten known related compounds (<b>7</b>⁻<b>16</b>) from the ethyl acetate (EtOAc) extract of soft coral <i>Sarcophyton stellatum</i>. The structures of the new compounds were established by extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy and data com  ...[more]

Similar Datasets

Unknown Targeted Isolation of Xenicane Diterpenoids from Taiwanese Soft Coral Asterospicularia laurae.
| S-EPMC7996537 | biostudies-literature
Unknown Isolation and structure elucidation of pentahydroxyscirpene, a trichothecene Fusarium mycotoxin.
| S-EPMC3903343 | biostudies-literature
Unknown Isolation of Lobane and Prenyleudesmane Diterpenoids from the Soft Coral <i>Lobophytum varium</i>.
| S-EPMC7230303 | biostudies-literature
Unknown Isolation, structure elucidation, and synthesis of antiplasmodial quinolones from Crinum firmifolium.
| S-EPMC5557408 | biostudies-literature
Unknown Isolation, Structure Elucidation, and Absolute Configuration of Germacrane Isomers from Carpesium divaricatum.
| S-EPMC6102216 | biostudies-literature
Unknown Isolation, structure elucidation, and biological evaluation of 16,23-epoxycucurbitacin constituents from Eleaocarpus chinensis.
| S-EPMC3311738 | biostudies-literature
Unknown New Antiproliferative Triflavanone from Thymelaea hirsuta-Isolation, Structure Elucidation and Molecular Docking Studies.
| S-EPMC7867015 | biostudies-literature
Unknown Isolation of Sesquiterpenoids and Steroids from the Soft Coral Sinularia brassica and Determination of Their Absolute Configuration.
| S-EPMC8466225 | biostudies-literature
Unknown Isolation, Characterization and Structure Elucidation of a Novel Lantibiotic From <i>Paenibacillus</i> sp.
| S-EPMC7721686 | biostudies-literature
Unknown Isolation and structure elucidation of GM4-type gangliosides from the Okinawan starfish Protoreaster nodosus.
| S-EPMC3509529 | biostudies-literature