Ontology highlight
ABSTRACT:
SUBMITTER: Grasberger H
PROVIDER: S-EPMC6033893 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Grasberger Helmut H Noureldin Mohamed M Kao Timothy D TD Adler Jeremy J Lee Joyce M JM Bishu Shrinivas S El-Zaatari Mohamad M Kao John Y JY Waljee Akbar K AK
Scientific reports 20180705 1
Loss-of-function mutations in dual oxidase (DUOX) 2 are the most common genetic variants found in congenital hypothyroidism (CH), and similar mutations have been recently reported in few very-early-onset inflammatory bowel disease (IBD) patients without CH. If DUOX2 variants indeed increase susceptibility for IBD, the enrichment of DUOX2 mutation carriers among CH patients should be reflected in higher risk for developing IBD. Using a database containing health insurance claims data for over 230 ...[more]