Unknown

Dataset Information

0

Increased risk for inflammatory bowel disease in congenital hypothyroidism supports the existence of a shared susceptibility factor.


ABSTRACT: Loss-of-function mutations in dual oxidase (DUOX) 2 are the most common genetic variants found in congenital hypothyroidism (CH), and similar mutations have been recently reported in few very-early-onset inflammatory bowel disease (IBD) patients without CH. If DUOX2 variants indeed increase susceptibility for IBD, the enrichment of DUOX2 mutation carriers among CH patients should be reflected in higher risk for developing IBD. Using a database containing health insurance claims data for over 230 million patients in the United States, 42,922 subjects with CH were identified based on strict inclusion criteria using diagnostic codes. For subgroup analysis, CH patients with pharmacy records were stratified as transient or permanent CH based on the absence or presence of levothyroxine treatment, respectively. Patients were matched to an equal-sized, age- and gender-matched non-CH group. Compared to controls, CH patients had a 73% higher overall IBD prevalence (0.52% vs 0.30%; P?

SUBMITTER: Grasberger H 

PROVIDER: S-EPMC6033893 | biostudies-other | 2018 Jul

REPOSITORIES: biostudies-other

altmetric image

Publications

Increased risk for inflammatory bowel disease in congenital hypothyroidism supports the existence of a shared susceptibility factor.

Grasberger Helmut H   Noureldin Mohamed M   Kao Timothy D TD   Adler Jeremy J   Lee Joyce M JM   Bishu Shrinivas S   El-Zaatari Mohamad M   Kao John Y JY   Waljee Akbar K AK  

Scientific reports 20180705 1


Loss-of-function mutations in dual oxidase (DUOX) 2 are the most common genetic variants found in congenital hypothyroidism (CH), and similar mutations have been recently reported in few very-early-onset inflammatory bowel disease (IBD) patients without CH. If DUOX2 variants indeed increase susceptibility for IBD, the enrichment of DUOX2 mutation carriers among CH patients should be reflected in higher risk for developing IBD. Using a database containing health insurance claims data for over 230  ...[more]

Similar Datasets

| S-EPMC4881818 | biostudies-literature
| S-EPMC8776955 | biostudies-literature
| S-EPMC7352130 | biostudies-literature
| S-EPMC10160392 | biostudies-literature
| S-EPMC2838486 | biostudies-literature
| S-EPMC7093074 | biostudies-literature
| S-EPMC4087674 | biostudies-literature
| S-EPMC8985479 | biostudies-literature
| S-EPMC7266893 | biostudies-literature
| S-EPMC8701029 | biostudies-literature