Ontology highlight
ABSTRACT:
SUBMITTER: Fang X
PROVIDER: S-EPMC6050291 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Fang Xiaona X Liu Qiong Q Bohrer Christopher C Hensel Zach Z Han Wei W Wang Jin J Xiao Jie J
Nature communications 20180717 1
Bistable switches are common gene regulatory motifs directing two mutually exclusive cell fates. Theoretical studies suggest that bistable switches are sufficient to encode more than two cell fates without rewiring the circuitry due to the non-equilibrium, heterogeneous cellular environment. However, such a scenario has not been experimentally observed. Here by developing a new, dual single-molecule gene-expression reporting system, we find that for the two mutually repressing transcription fact ...[more]