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AccuMUlate: a mutation caller designed for mutation accumulation experiments.


ABSTRACT: Summary:Mutation accumulation (MA) is the most widely used method for directly studying the effects of mutation. By sequencing whole genomes from MA lines, researchers can directly study the rate and molecular spectra of spontaneous mutations and use these results to understand how mutation contributes to biological processes. At present there is no software designed specifically for identifying mutations from MA lines. Here we describe accuMUlate, a probabilistic mutation caller that reflects the design of a typical MA experiment while being flexible enough to accommodate properties unique to any particular experiment. Availability and implementation accuMUlate is available from https://github.com/dwinter/accuMUlate. Supplementary information:Supplementary data are available at Bioinformatics online.

SUBMITTER: Winter DJ 

PROVIDER: S-EPMC6061804 | biostudies-other | 2018 Aug

REPOSITORIES: biostudies-other

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accuMUlate: a mutation caller designed for mutation accumulation experiments.

Winter David J DJ   Wu Steven H SH   Howell Abigail A AA   Azevedo Ricardo B R RBR   Zufall Rebecca A RA   Cartwright Reed A RA  

Bioinformatics (Oxford, England) 20180801 15


<h4>Summary</h4>Mutation accumulation (MA) is the most widely used method for directly studying the effects of mutation. By sequencing whole genomes from MA lines, researchers can directly study the rate and molecular spectra of spontaneous mutations and use these results to understand how mutation contributes to biological processes. At present there is no software designed specifically for identifying mutations from MA lines. Here we describe accuMUlate, a probabilistic mutation caller that re  ...[more]

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