Ontology highlight
ABSTRACT:
SUBMITTER: McLean FH
PROVIDER: S-EPMC6086894 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
McLean Fiona H FH Grant Christine C Morris Amanda C AC Horgan Graham W GW Polanski Alex J AJ Allan Kevin K Campbell Fiona M FM Langston Rosamund F RF Williams Lynda M LM
Scientific reports 20180810 1
Alzheimer's disease is a leading cause of morbidity and mortality with no cure and only limited treatment available. Obesity and type 2 diabetes are positively associated with the development of premature cognitive decline and Alzheimer's disease, linking diet with these conditions. Here we demonstrate that in mice episodic memory, together with spatial and contextual associative memory, is compromised after only one day of high-fat diet. However, object memory remains intact. This shows not onl ...[more]