Ontology highlight
ABSTRACT:
SUBMITTER: White JP
PROVIDER: S-EPMC6093087 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
White James P JP Billin Andrew N AN Campbell Milton E ME Russell Alan J AJ Huffman Kim M KM Kraus William E WE
Stem cell reports 20180719 2
Skeletal muscle stem cell (MuSC) function declines with age and contributes to impaired muscle regeneration in older individuals. Acting through AMPK/p27<sup>Kip1</sup>, we have identified a pathway regulating the balance between autophagy, apoptosis, and senescence in aged MuSCs. While p27<sup>Kip1</sup> is implicated in MuSC aging, its precise role and molecular mechanism have not been elucidated. Age-related MuSC dysfunction was associated with reduced autophagy, increased apoptosis, and hypo ...[more]