Ontology highlight
ABSTRACT:
SUBMITTER: Zou H
PROVIDER: S-EPMC6093908 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Zou Haixia H Liu Qian Q Meng Li L Zhou Jingye J Da Chenxiao C Wu Xikun X Jiang Lichun L Shou Jianyong J Hua Haiqing H
NPJ genomic medicine 20180815
Insulin resistance is a pathophysiological hallmark of type 2 diabetes and nonalcoholic fatty liver disease. Under the condition of fat accumulation in the liver, suppression of hepatic glucose production by insulin is diminished. In order to gain deeper understanding of dysregulation of glucose production in metabolic diseases, in the present study, we performed an unbiased phenotypic screening in primary human hepatocytes to discover novel mechanisms that regulate gluconeogenesis in the presen ...[more]