Ontology highlight
ABSTRACT:
SUBMITTER: Wangensteen KJ
PROVIDER: S-EPMC4421979 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Wangensteen Kirk J KJ Zhang Sophia S Greenbaum Linda E LE Kaestner Klaus H KH
Genes & development 20150501 9
The fundamental question of which genes are most important in controlling liver regeneration remains unanswered. We employed a parallel screen to test the impact of 43 selected genes on liver repopulation in the Fah(-/-) mouse model of hereditary tyrosinemia. We discovered that the transcription factor Foxa3 was a strong promoter of liver regeneration, while tumor necrosis factor receptor 1 (TNFR1) was the most significant suppressor of repopulation among all of the genes tested. Our approach en ...[more]