Ontology highlight
ABSTRACT:
SUBMITTER: Bortz DM
PROVIDER: S-EPMC6098086 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20180327 10
The medial septum (MS) impacts hippocampal activity and the hippocampus, in turn, regulates midbrain dopamine (DA) neuron activity. However, it remains to be determined how MS activation impacts midbrain DA activity. This question was addressed by infusing NMDA (0.75 µg/0.2 µL) into the medial septum of anesthetized male Sprague-Dawley rats and recording dopamine neuron activity in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). MS activation increased (71%) the number ...[more]