Age-mediated transcriptomic changes in adult mouse substantia nigra and ventral tegmental area
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Lin Gao
PROVIDER: E-GEOD-45045 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Age-mediated transcriptomic changes in adult mouse substantia nigra.
Gao Lin L Hidalgo-Figueroa María M Escudero Luis M LM Díaz-Martín Juan J López-Barneo José J Pascual Alberto A
PloS one 20130430 4
Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease (PD). Until now, molecular mechanisms behind SNpc aging have not been fully investigated using high throughput techniques. Here, we show early signs of aging in SNpc, which are more evident than in ventral tegmental area (VTA), a region adjacent to SNpc but less affected in PD. Aging-associated early changes in transcriptome were investigated comparing late middle-aged (18 ...[more]
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