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Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated o-Quinone Methides.


ABSTRACT: An efficient and practical approach towards bifunctional phosphorus phenols has been developed through a reaction of diphenylphosphine oxide and the o-quinone methides in situ generated from 2-tosylalkyl phenols under basic conditions. This protocol features simple experimental procedures under mild conditions and is easily scaled up. With this method, a variety of diarylmethyl phosphine oxides can be produced with up to 92% yield.

SUBMITTER: Chen Z 

PROVIDER: S-EPMC6100389 | biostudies-other | 2018 May

REPOSITORIES: biostudies-other

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Straightforward Synthesis of Bifunctional Phosphorus Phenols via Phosphination of In Situ Generated <i>o</i>-Quinone Methides.

Chen Zhangpei Z   Shi Qinglong Q   Wang Gongshu G   Chen Siwen S   Hu Jianshe J  

Molecules (Basel, Switzerland) 20180523 6


An efficient and practical approach towards bifunctional phosphorus phenols has been developed through a reaction of diphenylphosphine oxide and the <i>o</i>-quinone methides in situ generated from 2-tosylalkyl phenols under basic conditions. This protocol features simple experimental procedures under mild conditions and is easily scaled up. With this method, a variety of diarylmethyl phosphine oxides can be produced with up to 92% yield. ...[more]

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