Ontology highlight
ABSTRACT:
SUBMITTER: Huang C
PROVIDER: S-EPMC3250381 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20111018 44
A silanol-directed, Pd-catalyzed C-H oxygenation of phenols into catechols is presented. This method is highly site selective and general, as it allows for oxygenation of not only electron-neutral but also electron-poor phenols. This method operates via a silanol-directed acetoxylation, followed by a subsequent acid-catalyzed cyclization reaction into a cyclic silicon-protected catechol. A routine desilylation of the silacyle with TBAF uncovers the catechol product. ...[more]