Unknown

Dataset Information

0

MiR?140?5p regulates cell migration and invasion of non?small cell lung cancer cells through targeting VEGFA.

ABSTRACT: Lung cancer is the most common type of cancer worldwide, the most prevalent form of which is non?small cell lung cancer (NSCLC). MicroRNAs (miRs) are involved in the progression of NSCLC; however, the specific function of miR?140?5p in NSCLC remains unclear. The present study demonstrated that miR?140?5p was downregulated in the tumor tissues of patients with NSCLC, and it was associated with a poor prognosis. Furthermore, miR?140?5p significantly suppressed cell migration and invasion of the NSCLC cell line A549. In addition, the direct regulatory effect of miR?140?5p on vascular endothelial growth factor?A (VEGFA) was predicted by TargetScan and verified using a luciferase reporter gene assay. The present study also hypothesized that miR?140?5p may inhibit the expression of phosphorylated?protein kinase B by targeting VEGFA. In conclusion, miR?140?5p may be a potential target for the development of anti?neoplastic therapies in lung cancer.

SUBMITTER: Yang P 

PROVIDER: S-EPMC6102653 | biostudies-other | 2018 Sep

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

miR‑140‑5p regulates cell migration and invasion of non‑small cell lung cancer cells through targeting VEGFA.

Yang Peixia P   Xiong Jie J   Zuo Lin L   Liu Kequn K   Zhang Houbin H  

Molecular medicine reports 20180716 3

Lung cancer is the most common type of cancer worldwide, the most prevalent form of which is non‑small cell lung cancer (NSCLC). MicroRNAs (miRs) are involved in the progression of NSCLC; however, the specific function of miR‑140‑5p in NSCLC remains unclear. The present study demonstrated that miR‑140‑5p was downregulated in the tumor tissues of patients with NSCLC, and it was associated with a poor prognosis. Furthermore, miR‑140‑5p significantly suppressed cell migration and invasion of the NS  ...[more]

Similar Datasets

Unknown MiR-16-5p regulates postmenopausal osteoporosis by directly targeting VEGFA.
| S-EPMC7288956 | biostudies-literature
Unknown miR-769-5p suppressed cell proliferation, migration and invasion by targeting TGFBR1 in non-small cell lung carcinoma.
| S-EPMC5768346 | biostudies-literature
Unknown miR-150-5p inhibits hepatoma cell migration and invasion by targeting MMP14.
| S-EPMC4280173 | biostudies-literature
Unknown miR-29a-5p Regulates the Proliferation, Invasion, and Migration of Gliomas by Targeting DHRS4.
| S-EPMC7511594 | biostudies-literature
Unknown miR-140-5p regulates adipocyte differentiation by targeting transforming growth factor-? signaling.
| S-EPMC4676041 | biostudies-literature
Unknown miR-140-5p suppresses the proliferation, migration and invasion of gastric cancer by regulating YES1.
| S-EPMC5561618 | biostudies-literature
Unknown miR-29a-3p inhibits endometrial cancer cell proliferation, migration and invasion by targeting VEGFA/CD C42/PAK1.
| S-EPMC8293590 | biostudies-literature
Unknown miR-9-5p Promotes Lung Adenocarcinoma Cell Proliferation, Migration and Invasion by Targeting ID4.
| S-EPMC8564129 | biostudies-literature
Unknown MiR-302a-5p suppresses cell proliferation and invasion in non-small cell lung carcinoma by targeting ITGA6.
| S-EPMC6684888 | biostudies-other
Unknown MiR-200a Regulates Nasopharyngeal Carcinoma Cell Migration and Invasion by Targeting MYH10.
| S-EPMC7086266 | biostudies-literature