Ontology highlight
ABSTRACT:
SUBMITTER: Jin C
PROVIDER: S-EPMC6108082 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Journal of medicinal chemistry 20180730 15
The orphan G-protein-coupled receptor GPR88 is highly expressed in the striatum. Studies using GPR88 knockout mice have suggested that the receptor is implicated in alcohol seeking and drinking behaviors. To date, the biological effects of GPR88 activation are still unknown due to the lack of a potent and selective agonist appropriate for in vivo investigation. In this study, we report the discovery of the first potent, selective, and brain-penetrant GPR88 agonist RTI-13951-33 (6). RTI-13951-33 ...[more]