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Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes.

ABSTRACT: A highly diastereo- and enantioselective protocol for the hydroallylation of 1,1- and 1,2-disubstituted cyclopropenes has been developed utilizing an in situ formed copper hydride. A variety of allyl electrophiles could be utilized yielding a diverse range of trisubstituted cyclopropanes. Finally a preliminary enantioselective variant could be established employing a recently described P-stereogenic xantphos derivative as ligand.

SUBMITTER: Sommer H

PROVIDER: S-EPMC6115688 | biostudies-other | 2018 Aug

REPOSITORIES: biostudies-other

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Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes.

Sommer Heiko H Marek Ilan I

Chemical science 20180702 31

A highly diastereo- and enantioselective protocol for the hydroallylation of 1,1- and 1,2-disubstituted cyclopropenes has been developed utilizing an <i>in situ</i> formed copper hydride. A variety of allyl electrophiles could be utilized yielding a diverse range of trisubstituted cyclopropanes. Finally a preliminary enantioselective variant could be established employing a recently described <i>P</i>-stereogenic xantphos derivative as ligand. ...[more]

PMID: 30310580

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