Dataset Information
Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes.
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ABSTRACT:
SUBMITTER: Sommer H
PROVIDER: S-EPMC6115688 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Publications
Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes.
Chemical science 20180702 31
A highly diastereo- and enantioselective protocol for the hydroallylation of 1,1- and 1,2-disubstituted cyclopropenes has been developed utilizing an <i>in situ</i> formed copper hydride. A variety of allyl electrophiles could be utilized yielding a diverse range of trisubstituted cyclopropanes. Finally a preliminary enantioselective variant could be established employing a recently described <i>P</i>-stereogenic xantphos derivative as ligand. ...[more]