Ontology highlight
ABSTRACT:
SUBMITTER: Adrianse RL
PROVIDER: S-EPMC6118007 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Adrianse Robin L RL Smith Kaleb K Gatbonton-Schwager Tonibelle T Sripathy Smitha P SP Lao Uyen U Foss Eric J EJ Boers Ruben G RG Boers Joachim B JB Gribnau Joost J Bedalov Antonio A
Epigenetics & chromatin 20180831 1
<h4>Background</h4>The long noncoding RNA Xist is critical for initiation and establishment of X-chromosome inactivation during embryogenesis in mammals, but it is unclear whether its continued expression is required for maintaining X-inactivation in vivo.<h4>Results</h4>By using an inactive X-chromosome-linked MeCP2-GFP reporter, which allowed us to enumerate reactivation events in the mouse brain even when they occur in very few cells, we found that deletion of Xist in the brain after establis ...[more]