Ontology highlight
ABSTRACT:
SUBMITTER: Sawicki KT
PROVIDER: S-EPMC6124529 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Sawicki Konrad T KT Chang Hsiang-Chun HC Shapiro Jason S JS Bayeva Marina M De Jesus Adam A Finck Brian N BN Wertheim Jason A JA Blackshear Perry J PJ Ardehali Hossein H
JCI insight 20180712 13
The role of posttranscriptional metabolic gene regulatory programs in diabetes is not well understood. Here, we show that the RNA-binding protein tristetraprolin (TTP) is reduced in the livers of diabetic mice and humans and is transcriptionally induced in response to insulin treatment in murine livers in vitro and in vivo. Liver-specific Ttp-KO (lsTtp-KO) mice challenged with high-fat diet (HFD) have improved glucose tolerance and peripheral insulin sensitivity compared with littermate controls ...[more]