Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury.
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ABSTRACT:
SUBMITTER: Thibodeau A
PROVIDER: S-EPMC6126256 | biostudies-other | 2016 Apr-Jun
REPOSITORIES: biostudies-other
Publications
Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury.
Thibodeau Alexa A Geng Xiaokun X Previch Lauren E LE Ding Yuchuan Y
Brain circulation 20160401 2
Pyruvate dehydrogenase (PDH) complex is a mitochondrial matrix enzyme that serves a critical role in the conversion of anaerobic to aerobic cerebral energy. The regulatory complexity of PDH, coupled with its significant influence in brain metabolism, underscores its susceptibility to, and significance in, ischemia-reperfusion injury. Here, we evaluate proposed mechanisms of PDH-mediated neurodysfunction in stroke, including oxidative stress, altered regulatory enzymatic control, and loss of PDH ...[more]
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