Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen DC
PROVIDER: S-EPMC6135805 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Nguyen Doan C DC Garimalla Swetha S Xiao Haopeng H Kyu Shuya S Albizua Igor I Galipeau Jacques J Chiang Kuang-Yueh KY Waller Edmund K EK Wu Ronghu R Gibson Greg G Roberson James J Lund Frances E FE Randall Troy D TD Sanz Iñaki I Lee F Eun-Hyung FE
Nature communications 20180912 1
Human antibody-secreting cells (ASC) in peripheral blood are found after vaccination or infection but rapidly apoptose unless they migrate to the bone marrow (BM). Yet, elements of the BM microenvironment required to sustain long-lived plasma cells (LLPC) remain elusive. Here, we identify BM factors that maintain human ASC > 50 days in vitro. The critical components of the cell-free in vitro BM mimic consist of products from primary BM mesenchymal stromal cells (MSC), a proliferation-inducing li ...[more]