Ontology highlight
ABSTRACT:
SUBMITTER: Michaux A
PROVIDER: S-EPMC6137107 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Michaux Arnaud A Matagrin Benjamin B Debaux Jean-Valéry JV Schurgers Leon J LJ Benoit Etienne E Lattard Virginie V
Scientific reports 20180913 1
Vitamin K plays a crucial role in the regulation of vascular calcifications by allowing activation of matrix Gla protein. The dietary requirement for vitamin K is low because of an efficient recycling of vitamin K by vitamin K epoxide reductase (VKORC1). However, decreased VKORC1 activity may result in vascular calcification. More than 30 coding mutations of VKORC1 have been described. While these mutations have been suspected of causing anticoagulant resistance, their association with an increa ...[more]