Catalyst-dependent selectivity in sulfonium ylide cycloisomerization reactions.

ABSTRACT: Divergent catalysis is an emerging field whereby access to structurally diverse compounds from a common precursor is achieved through controlled reaction pathways. Herein we present an unusual example of ?-acid catalyst dependent selectivity in the cycloisomerization of alkene-tethered sulfonium ylides. Computational mechanistic studies revealed how the ability of palladium to cycle through oxidation states largely controls the selectivity.

SUBMITTER: Oost R 

PROVIDER: S-EPMC6137435 | biostudies-other | 2018 Sep

REPOSITORIES: biostudies-other