Ontology highlight
ABSTRACT:
SUBMITTER: Mutreja K
PROVIDER: S-EPMC6137818 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Mutreja Karun K Krietsch Jana J Hess Jeannine J Ursich Sebastian S Berti Matteo M Roessler Fabienne K FK Zellweger Ralph R Patra Malay M Gasser Gilles G Lopes Massimo M
Cell reports 20180901 10
Interstrand cross-links (ICLs) are toxic DNA lesions interfering with DNA metabolism that are induced by widely used anticancer drugs. They have long been considered absolute roadblocks for replication forks, implicating complex DNA repair processes at stalled or converging replication forks. Recent evidence challenged this view, proposing that single forks traverse ICLs by yet elusive mechanisms. Combining ICL immunolabeling and single-molecule approaches in human cells, we now show that ICL in ...[more]