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Three-dimensional free breathing whole heart cardiovascular magnetic resonance T1 mapping at 3 T.


ABSTRACT: This study demonstrates a three-dimensional (3D) free-breathing native myocardial T1 mapping sequence at 3 T.The proposed sequence acquires three differently T1-weighted volumes. The first two volumes receive a saturation pre-pulse with different recovery time. The third volume is acquired without magnetization preparation and after a significant recovery time. Respiratory navigator gating and volume-interleaved acquisition are adopted to mitigate misregistration. The proposed sequence was validated through simulation, phantom experiments and in vivo experiments in 12 healthy adult subjects.In phantoms, good agreement on T1 measurement was achieved between the proposed sequence and the reference inversion recovery spin echo sequence (R2?=?0.99). Homogeneous 3D T1 maps were obtained from healthy adult subjects, with a T1 value of 1476?±?53 ms and a coefficient of variation (CV) of 6.1?±?1.4% over the whole left-ventricular myocardium. The averaged septal T1 was 1512?±?60 ms with a CV of 2.1?±?0.5%.Free-breathing 3D native T1 mapping at 3 T is feasible and may be applicable in myocardial assessment. The proposed 3D T1 mapping sequence is suitable for applications in which larger coverage is desired beyond that available with single-shot parametric mapping, or breath-holding is unfeasible.

SUBMITTER: Guo R 

PROVIDER: S-EPMC6139904 | biostudies-other | 2018 Sep

REPOSITORIES: biostudies-other

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Three-dimensional free breathing whole heart cardiovascular magnetic resonance T<sub>1</sub> mapping at 3 T.

Guo Rui R   Chen Zhensen Z   Wang Yishi Y   Herzka Daniel A DA   Luo Jianwen J   Ding Haiyan H  

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20180917 1


<h4>Background</h4>This study demonstrates a three-dimensional (3D) free-breathing native myocardial T<sub>1</sub> mapping sequence at 3 T.<h4>Methods</h4>The proposed sequence acquires three differently T<sub>1</sub>-weighted volumes. The first two volumes receive a saturation pre-pulse with different recovery time. The third volume is acquired without magnetization preparation and after a significant recovery time. Respiratory navigator gating and volume-interleaved acquisition are adopted to  ...[more]

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