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Sigma Receptor (?R) Ligands with Antiproliferative and Anticancer Activity.

ABSTRACT: Sigma receptor (?R) ligands have proven to be useful as cancer diagnostics and anticancer therapeutics and their ligands have been developed as molecular probes in oncology. Moreover, various ?R ligands generate cancer cell death in vitro and in vivo. These ?R ligands have exhibited promising results against numerous human and rodent cancers and are investigated under preclinical and clinical study trials, indicating a new category of drugs in cancer therapy.

SUBMITTER: Georgiadis MO 

PROVIDER: S-EPMC6151391 | biostudies-other | 2017 Aug

REPOSITORIES: biostudies-other

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Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity.

Georgiadis Markos-Orestis MO   Karoutzou Olga O   Foscolos Angeliki-Sofia AS   Papanastasiou Ioannis I  

Molecules (Basel, Switzerland) 20170825 9

Sigma receptor (σR) ligands have proven to be useful as cancer diagnostics and anticancer therapeutics and their ligands have been developed as molecular probes in oncology. Moreover, various σR ligands generate cancer cell death in vitro and in vivo. These σR ligands have exhibited promising results against numerous human and rodent cancers and are investigated under preclinical and clinical study trials, indicating a new category of drugs in cancer therapy. ...[more]

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