Dataset Information
Synthesis and Antitumor Activity of Triazole-Containing Sorafenib Analogs.
Ontology highlight
ABSTRACT:
SUBMITTER: Ye W
PROVIDER: S-EPMC6151694 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Publications
Synthesis and Antitumor Activity of Triazole-Containing Sorafenib Analogs.
Molecules (Basel, Switzerland) 20171024 10
Using a highly effective binuclear Cu complex as the catalyst, the 1,3-dipolar cycloaddition reactions between 16 alkynes and two azides were successfully performed and resulted in the production of 25 new triazole-containing sorafenib analogs. Several compounds were evaluated as potent antitumor agents. Among them, 4-(4-(4-(3-fluorophenyl)-1<i>H</i>-1,2,3-triazol-1-yl)phenoxy)-<i>N</i>-methylpicolinamide (<b>8f</b>) potently suppressed the proliferation of HT-29 cancer cells by inducing apoptos ...[more]