Ontology highlight
ABSTRACT:
SUBMITTER: Xia X
PROVIDER: S-EPMC6155249 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Xia Xiaohong X Liao Yuning Y Guo Zhiqiang Z Li Yanling Y Jiang Lili L Zhang Fangcheng F Huang Chuyi C Liu Yuan Y Wang Xuejun X Liu Ningning N Liu Jinbao J Huang Hongbiao H
Oncogenesis 20180924 9
Estrogen receptor α (ERα) is expressed in ~67% of breast cancers and is critical to their proliferation and progression. The expression of ERα is regarded as a major prognostic marker, making it a meaningful target to treat breast cancer (BCa). However, hormone receptor-positive BCa was sometimes irresponsive or even resistant to classic anti-hormonal therapies (e.g., fulvestrant and tamoxifen). Hence, novel anti-endocrine therapies are urgent for ERα<sup>+</sup> BCa. A phase II study suggested ...[more]