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Ent-Abietanoids Isolated from Isodon serra.

ABSTRACT: Four new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified as rubescansin J (5), (3?,14?)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7), and enanderianin P (8), respectively. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature. Compound 1 showed remarkable inhibitory activity towards NO production in LPS-stimulated RAW264.7 cells (IC50 = 1.8 ?M) and weak cytotoxicity towards five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480).

SUBMITTER: Wan J

PROVIDER: S-EPMC6155895 | biostudies-other | 2017 Feb

REPOSITORIES: biostudies-other

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Ent-Abietanoids Isolated from Isodon serra.

Wan Jun J Jiang Hua-Yi HY Tang Jian-Wei JW Li Xing-Ren XR Du Xue X Li Yan Y Sun Han-Dong HD Pu Jian-Xin JX

Molecules (Basel, Switzerland) 20170217 2

Four new ent-abietane diterpenoids, along with four known ones were isolated from the aerial parts of Isodon serra, a traditional Chinese folk medicine. The new diterpenoids were named as serrin K (1), xerophilusin XVII (2), and enanderianins Q and R (3 and 4), while the known ones were identified as rubescansin J (5), (3α,14β)-3,18-[(1-methylethane-1,1-diyl)dioxy]-ent-abieta-7,15(17)-diene-14,16-diol (6), xerophilusin XIV (7) ...[more]

PMID: 28218684

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