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The Infinity War: How to Cope with Carbapenem-resistant Enterobacteriaceae.

ABSTRACT: Carbapenem-resistant Enterobacteriaceae (CRE) are now spread worldwide. In Korea, the number of CRE isolation is rapidly increasing, and impending endemicity is a concern. To cope well with CRE, thorough infection control, such as active surveillance, early detection, strict contact precaution, cleaning the environment, and antibiotic stewardship is very important. Therapeutic options include polymyxin, tigecycline, fosfomycin or the combination of them with carbapenem, which is currently the mainstay of treatment. In addition, various combination regimens with new carbapenemase inhibitors such as avibactam, vaborbactam, or relebactam, and other classes of antimicrobials such as plazomicin and siderophore cephalosporin are in the process of evaluation.

SUBMITTER: Yoo JH

PROVIDER: S-EPMC6159103 | biostudies-other | 2018 Oct

REPOSITORIES: biostudies-other

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The Infinity War: How to Cope with Carbapenem-resistant <i>Enterobacteriaceae</i>.

Yoo Jin-Hong JH

Journal of Korean medical science 20180903 40

Carbapenem-resistant <i>Enterobacteriaceae</i> (CRE) are now spread worldwide. In Korea, the number of CRE isolation is rapidly increasing, and impending endemicity is a concern. To cope well with CRE, thorough infection control, such as active surveillance, early detection, strict contact precaution, cleaning the environment, and antibiotic stewardship is very important. Therapeutic options include polymyxin, tigecycline, fosfomycin or the combination of them with carbapenem, which is currently ...[more]

PMID: 30275806

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