Ontology highlight
ABSTRACT:
SUBMITTER: Chen CC
PROVIDER: S-EPMC6162454 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Chen Chin-Chuan CC Chen Chi-Yuan CY Wang Shu-Huei SH Yeh Chau-Ting CT Su Shih-Chi SC Ueng Shir-Hwa SH Chuang Wen-Yu WY Hsueh Chuen C Wang Tong-Hong TH
Cancers 20180910 9
DNA repair systems are abnormally active in most hepatocellular carcinoma (HCC) cells due to accumulated mutations, resulting in elevated DNA repair capacity and resistance to chemotherapy and radiotherapy. Thus, targeting DNA repair mechanisms is a common treatment approach in HCC to sensitize cancer cells to DNA damage. In this study, we examined the anti-HCC effects of melatonin and elucidated the regulatory mechanisms. The results of functional assays showed that in addition to inhibiting th ...[more]