Ontology highlight
ABSTRACT:
SUBMITTER: Martins D
PROVIDER: S-EPMC6166797 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Martins Dorival D McKay Geoffrey G Sampathkumar Gowthami G Khakimova Malika M English Ann M AM Nguyen Dao D
Proceedings of the National Academy of Sciences of the United States of America 20180910 39
Metabolically quiescent bacteria represent a large proportion of those in natural and host environments, and they are often refractory to antibiotic treatment. Such drug tolerance is also observed in the laboratory during stationary phase, when bacteria face stress and starvation-induced growth arrest. Tolerance requires (p)ppGpp signaling, which mediates the stress and starvation stringent response (SR), but the downstream effectors that confer tolerance are unclear. We previously demonstrated ...[more]