Defining Lineage-Specific Membrane Fluidity Signatures that Regulate Adhesion Kinetics.
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ABSTRACT:
SUBMITTER: Matsuzaki T
PROVIDER: S-EPMC6178887 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Publications
Defining Lineage-Specific Membrane Fluidity Signatures that Regulate Adhesion Kinetics.
Matsuzaki Takahisa T Matsumoto Shinya S Kasai Toshiharu T Yoshizawa Emi E Okamoto Satoshi S Yoshikawa Hiroshi Y HY Taniguchi Hideki H Takebe Takanori T
Stem cell reports 20180906 4
Cellular membrane fluidity is a critical modulator of cell adhesion and migration, prompting us to define the systematic landscape of lineage-specific cellular fluidity throughout differentiation. Here, we have unveiled membrane fluidity landscapes in various lineages ranging from human pluripotency to differentiated progeny: (1) membrane rigidification precedes the exit from pluripotency, (2) membrane composition modulates activin signaling transmission, and (3) signatures are relatively germ l ...[more]
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