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Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer.

ABSTRACT: Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC.

SUBMITTER: Park JL

PROVIDER: S-EPMC6187813 | biostudies-other | 2018 Sep

REPOSITORIES: biostudies-other

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Generation of Whole-Genome Sequencing Data for Comparing Primary and Castration-Resistant Prostate Cancer.

Park Jong-Lyul JL Kim Seon-Kyu SK Kim Jeong-Hwan JH Yun Seok Joong SJ Kim Wun-Jae WJ Kim Won Tae WT Jeong Pildu P Kang Ho Won HW Kim Seon-Young SY

Genomics & informatics 20180930 3

Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CR ...[more]

PMID: 30309206

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2011-12-06 | E-GEOD-34174 | biostudies-arrayexpress

Whole Genome Methylation Analysis of Metastatic Castration Resistant Prostate Cancer

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Expression data for primary localized prostate cancer versus castration-resistant bone metastatic prostate cancer

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Primary versus castration-resistant prostate cancer: modeling through novel murine prostate cancer cell lines.

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