Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC6189649 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Zhang Xinyue X Guo Jieyu J Wei Xiangxiang X Niu Cong C Jia Mengping M Li Qinhan Q Meng Dan D
Oxidative medicine and cellular longevity 20181002
The transcription factor BTB and CNC homology 1 (Bach1) is widely expressed in most mammalian tissues and functions primarily as a transcriptional suppressor by heterodimerizing with small Maf proteins and binding to Maf recognition elements in the promoters of targeted genes. It has a key regulatory role in the production of reactive oxygen species, cell cycle, heme homeostasis, hematopoiesis, and immunity and has been shown to suppress ischemic angiogenesis and promote breast cancer metastasis ...[more]