Ontology highlight
ABSTRACT:
SUBMITTER: Bhang DH
PROVIDER: S-EPMC6197186 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Nature communications 20181022 1
Maintenance of adult tissues depends on stem cell self-renewal in local niches. Spermatogonial stem cells (SSC) are germline adult stem cells necessary for spermatogenesis and fertility. We show that testicular endothelial cells (TECs) are part of the SSC niche producing glial cell line-derived neurotrophic factor (GDNF) and other factors to support human and mouse SSCs in long-term culture. We demonstrate that FGF-2 binding to FGFR1 on TECs activates the calcineurin pathway to produce GDNF. Com ...[more]