Ontology highlight
ABSTRACT:
SUBMITTER: Ashraf MW
PROVIDER: S-EPMC6202471 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Ashraf Muhammad W MW Peltoniemi Marko A MA Olkkola Klaus T KT Neuvonen Pertti J PJ Saari Teijo I TI
CPT: pharmacometrics & systems pharmacology 20180910 10
Low-dose oral S-ketamine is increasingly used in chronic pain therapy, but extensive cytochrome P450 (CYP) mediated metabolism makes it prone to pharmacokinetic drug-drug interactions (DDIs). In our study, concentration-time data from five studies were used to develop a semimechanistic model that describes the ticlopidine-mediated inhibition of S-ketamine biotransformation. A mechanistic model was implemented to account for reversible and time-dependent hepatic CYP2B6 inactivation by ticlopidine ...[more]