Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC6210900 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Zhang Xiang X Rimbert Antoine A Balder Willem W Zwinderman Aeilko Having AH Kuivenhoven Jan Albert JA Dallinga-Thie Geesje Margaretha GM Groen Albert Kornelis AK
Journal of lipid research 20180928 11
Hypercholesterolemia is characterized by high plasma LDL cholesterol and often caused by genetic mutations in LDL receptor (<i>LDLR</i>), <i>APOB</i>, or proprotein convertase subtilisin/kexin type 9 (<i>PCSK9</i>). However, a substantial proportion of hypercholesterolemic subjects do not have any mutations in these canonical genes, leaving the underlying pathobiology to be determined. In this study, we investigated to determine whether combining plasma metabolomics with genetic information incr ...[more]