Dataset Information

Network analysis of the NetHealth data: exploring co-evolution of individuals' social network positions and physical activities.

ABSTRACT: Understanding the relationship between individuals' social networks and health could help devise public health interventions for reducing incidence of unhealthy behaviors or increasing prevalence of healthy ones. In this context, we explore the co-evolution of individuals' social network positions and physical activities. We are able to do so because the NetHealth study at the University of Notre Dame has generated both high-resolution longitudinal social network (e.g., SMS) data and high-resolution longitudinal health-related behavioral (e.g., Fitbit physical activity) data. We examine trait differences between (i) users whose social network positions (i.e., centralities) change over time versus those whose centralities remain stable, (ii) users whose Fitbit physical activities change over time versus those whose physical activities remain stable, and (iii) users whose centralities and their physical activities co-evolve, i.e., correlate with each other over time. We find that centralities of a majority of all nodes change with time. These users do not show any trait difference compared to time-stable users. However, if out of all users whose centralities change with time we focus on those whose physical activities also change with time, then the resulting users are more likely to be introverted than time-stable users. Moreover, users whose centralities and physical activities both change with time and whose evolving centralities are significantly correlated (i.e., co-evolve) with evolving physical activities are more likely to be introverted as well as anxious compared to those users who are time-stable and do not have a co-evolution relationship. Our network analysis framework reveals several links between individuals' social network structure, health-related behaviors, and the other (e.g., personality) traits. In the future, our study could lead to development of a predictive model of social network structure from behavioral/trait information and vice versa.

SUBMITTER: Liu S

PROVIDER: S-EPMC6223883 | biostudies-other | 2018

REPOSITORIES: biostudies-other

ACCESS DATA

Publications

Network analysis of the NetHealth data: exploring co-evolution of individuals' social network positions and physical activities.

Liu Shikang S Hachen David D Lizardo Omar O Poellabauer Christian C Striegel Aaron A Milenković Tijana T

Applied network science 20181102 1

Understanding the relationship between individuals' social networks and health could help devise public health interventions for reducing incidence of unhealthy behaviors or increasing prevalence of healthy ones. In this context, we explore the co-evolution of individuals' social network positions and physical activities. We are able to do so because the NetHealth study at the University of Notre Dame has generated both high-resolution longitudinal social network (e.g., SMS) data and high-resolu ...[more]

PMID: 30465021

Similar Datasets

Project description:BACKGROUND:Contact tracing data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is used to estimate basic epidemiological parameters. Contact tracing data could also be potentially used for assessing the heterogeneity of transmission at the individual patient level. Characterization of individuals based on different levels of infectiousness could better inform the contact tracing interventions at field levels. METHODS:Standard social network analysis methods used for exploring infectious disease transmission dynamics was employed to analyze contact tracing data of 1959 diagnosed SARS-CoV-2 patients from a large state of India. Relational network data set with diagnosed patients as "nodes" and their epidemiological contact as "edges" was created. Directed network perspective was utilized in which directionality of infection emanated from a "source patient" towards a "target patient". Network measures of " degree centrality" and "betweenness centrality" were calculated to identify influential patients in the transmission of infection. Components analysis was conducted to identify patients connected as sub- groups. Descriptive statistics was used to summarise network measures and percentile ranks were used to categorize influencers. RESULTS:Out-degree centrality measures identified that of the total 1959 patients, 11.27% (221) patients have acted as a source of infection to 40.19% (787) other patients. Among these source patients, 0.65% (12) patients had a higher out-degree centrality (>?=?10) and have collectively infected 37.61% (296 of 787), secondary patients. Betweenness centrality measures highlighted that 7.50% (93) patients had a non-zero betweenness (range 0.5 to 135) and thus have bridged the transmission between other patients. Network component analysis identified nineteen connected components comprising of influential patient's which have overall accounted for 26.95% of total patients (1959) and 68.74% of epidemiological contacts in the network. CONCLUSIONS:Social network analysis method for SARS-CoV-2 contact tracing data would be of use in measuring individual patient level variations in disease transmission. The network metrics identified individual patients and patient components who have disproportionately contributed to transmission. The network measures and graphical tools could complement the existing contact tracing indicators and could help improve the contact tracing activities.

Project description:BACKGROUND: In pandemic and epidemic forms, avian and human influenza viruses often cause significant damage to human society and economics. Gradually accumulated mutations on hemagglutinin (HA) cause immunologically distinct circulating strains, which lead to the antigenic drift (named as antigenic variants). The "antigenic variants" often requires a new vaccine to be formulated before each annual epidemic. Mapping the genetic evolution to the antigenic drift of influenza viruses is an emergent issue to public health and vaccine development RESULTS: We developed a method for identifying antigenic critical amino acid positions, rules, and co-mutated positions for antigenic variants. The information gain (IG) and the entropy are used to measure the score of an amino acid position on hemagglutinin (HA) for discriminating between antigenic variants and similar viruses. A position with high IG and entropy implied that this position is highly correlated to an antigenic drift. Nineteen positions with high IG and high genetic diversity are identified as antigenic critical positions on the HA proteins. Most of these antigenic critical positions are located on five epitopes or on the surface based on the HA structure. Based on IG values and entropies of these 19 positions on the HA, the decision tree was applied to create a rule-based model and to identify rules for predicting antigenic variants of a given two HA sequences which are often a vaccine strain and a circulating strain. The predicting accuracies of this model on two sets, which consist of a training set (181 hemagglutination inhibition (HI) assays) and an independent test set (31,878 HI assays), are 91.2% and 96.2% respectively. CONCLUSION: Our method is able to identify critical positions, rules, and co-mutated positions on HA for predicting the antigenic variants. The information gains and the entropies of HA positions provide insight to the antigenic drift and co-evolution positions for influenza seasons. We believe that our method is robust and is potential useful for studying influenza virus evolution and vaccine development.

Dataset Information

Network analysis of the NetHealth data: exploring co-evolution of individuals' social network positions and physical activities.

Publications

Network analysis of the NetHealth data: exploring co-evolution of individuals' social network positions and physical activities.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets