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Synthesis and Cytotoxicities of Royleanone Derivatives.

ABSTRACT: Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11-C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro.

SUBMITTER: Li CJ

PROVIDER: S-EPMC6224808 | biostudies-other | 2018 Jun

REPOSITORIES: biostudies-other

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Synthesis and Cytotoxicities of Royleanone Derivatives.

Li Cheng-Ji CJ Xia Fan F Wu Rong R Tan Hong-Sheng HS Xu Hong-Xi HX Xu Gang G Qin Hong-Bo HB

Natural products and bioprospecting 20180616 6

Carnosic acid was used as starting material to synthesize royleanone derivatives featured C11-C14 para quinone. The importance of C-20 group of royleanone derivatives was verified by the cytotoxicity assay of royleanonic acid, miltionone I and deoxyneocrptotanshinone. Following our synthetic route, 15 amide derivatives were synthesized and 8 compounds exhibited moderate cytotoxic activities against three human cancer lines in vitro. ...[more]

PMID: 29909523

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