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Triterpenoids from Euphorbia maculata and Their Anti-Inflammatory Effects.

ABSTRACT: Euphorbia maculata is a medicinal plant of the Euphorbiaceae family, which can produce anti-inflammatory and cancer chemopreventive agents of triterpenoids. The present study reports on the bioactive triterpenoids of this plant. Two new lanostane-type triterpenoids, named (3S,4S,7S,9R)-4-methyl-3,7-dihydroxy-7(8?9) abeo-lanost-24(28)-en-8-one (1) and 24-hydroperoxylanost-7,25-dien-3?-ol (2), together with 15 known triterpene derivatives, were isolated from Euphorbia maculata. The structures of the new compounds were determined on the basis of extensive spectroscopic data (UV, MS, ¹H and 13C-NMR, and 2D NMR) analysis. All tetracyclic triterpenoids (1?11) were evaluated for their anti-inflammatory effects in the test of TPA-induced inflammation (1 ?g/ear) in mice. The triterpenes exhibited significant anti-inflammatory activities.

SUBMITTER: Sun Y

PROVIDER: S-EPMC6225269 | biostudies-other | 2018 Aug

REPOSITORIES: biostudies-other

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Triterpenoids from Euphorbia maculata and Their Anti-Inflammatory Effects.

Sun Yi Y Gao Liang-Liang LL Tang Meng-Yue MY Feng Bao-Min BM Pei Yue-Hu YH Yasukawa Ken K

Molecules (Basel, Switzerland) 20180822 9

Euphorbia maculata is a medicinal plant of the Euphorbiaceae family, which can produce anti-inflammatory and cancer chemopreventive agents of triterpenoids. The present study reports on the bioactive triterpenoids of this plant. Two new lanostane-type triterpenoids, named (3S,4S,7S,9R)-4-methyl-3,7-dihydroxy-7(8→9) abeo-lanost-24(28)-en-8-one (1) and 24-hydroperoxylanost-7,25-dien-3β-ol (2), together with 15 known triterpene derivatives, we ...[more]

PMID: 30135395

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