Ontology highlight
ABSTRACT:
SUBMITTER: Lopez Almeida L
PROVIDER: S-EPMC6234904 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Lopez Almeida Leonor L Sebbagh Michael M Bertucci François F Finetti Pascal P Wicinski Julien J Marchetto Sylvie S Castellano Rémy R Josselin Emmanuelle E Charafe-Jauffret Emmanuelle E Ginestier Christophe C Borg Jean-Paul JP Santoni Marie-Josée MJ
Stem cell reports 20181018 5
Tumor initiation, progression, and therapeutic resistance have been proposed to originate from a subset of tumor cells, cancer stem cells (CSCs). However, the current understanding of the mechanisms involved in their self-renewal and tumor initiation capacity remains limited. Here, we report that expression of LANO/LRRC1, the vertebrate paralog of SCRIB tumor suppressor, is associated with a stem cell signature in normal and tumoral mammary epithelia. Through in vitro and in vivo experiments inc ...[more]