Ontology highlight
ABSTRACT:
SUBMITTER: Sasaki F
PROVIDER: S-EPMC6237215 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Sasaki Fumiyuki F Koga Tomoaki T Ohba Mai M Saeki Kazuko K Okuno Toshiaki T Ishikawa Keijiro K Nakama Takahito T Nakao Shintaro S Yoshida Shigeo S Ishibashi Tatsuro T Ahmadieh Hamid H Kanavi Mozhgan Rezaei MR Hafezi-Moghadam Ali A Penninger Josef M JM Sonoda Koh-Hei KH Yokomizo Takehiko T
JCI insight 20180920 18
Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is associated with aging and is a leading cause of blindness worldwide. Here, we demonstrate that leukotriene B4 (LTB4) receptor 1 (BLT1) promotes laser-induced choroidal neovascularization (CNV) in a mouse model for wet-type AMD. CNV was significantly less in BLT1-deficient (BLT1-KO) mice compared with BLT1-WT controls. Expression of several proangiogenic and profibrotic factors was lower in BLT1-KO eye ...[more]