Ontology highlight
ABSTRACT:
SUBMITTER: Berry JA
PROVIDER: S-EPMC6239218 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Cell reports 20181001 3
It remains unclear how memory engrams are altered by experience, such as new learning, to cause forgetting. Here, we report that short-term aversive memory in Drosophila is encoded by and retrieved from the mushroom body output neuron MBOn-γ2α'1. Pairing an odor with aversive electric shock creates a robust depression in the calcium response of MBOn-γ2α'1 and increases avoidance to the paired odor. Electric shock after learning, which activates the cognate dopamine neuron DAn-γ2α'1, restores the ...[more]