Dataset Information
Redox-triggered cascade dearomative cyclizations enabled by hexafluoroisopropanol.
Ontology highlight
ABSTRACT:
SUBMITTER: Li SS
PROVIDER: S-EPMC6240893 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Publications
Redox-triggered cascade dearomative cyclizations enabled by hexafluoroisopropanol.
Chemical science 20180913 43
An unprecedented cascade dearomative cyclization through hydrogen-bonding-assisted hydride transfer is realized. The aggregate effect of HFIP enables the rapid buildup of polycyclic amines directly from phenols and <i>o</i>-aminobenzaldehydes <i>via</i> a cascade dearomatization/rearomatization/dearomatization sequence. This unique transformation addressed the drawbacks of hydride transfer-involved redox-neutral reactions. ...[more]