Ontology highlight
ABSTRACT:
SUBMITTER: Fujita Y
PROVIDER: S-EPMC6257700 | biostudies-other | 2010
REPOSITORIES: biostudies-other
Fujita Yuki Y Ishikawa Junya J Furuta Hiroyuki H Ikawa Yoshiya Y
Molecules (Basel, Switzerland) 20100826 9
In vitro selection with long random RNA libraries has been used as a powerful method to generate novel functional RNAs, although it often requires laborious structural analysis of isolated RNA molecules. Rational RNA design is an attractive alternative to avoid this laborious step, but rational design of catalytic modules is still a challenging task. A hybrid strategy of in vitro selection and rational design has been proposed. With this strategy termed "design and selection," new ribozymes can ...[more]