Ontology highlight
ABSTRACT:
SUBMITTER: Mu X
PROVIDER: S-EPMC6262859 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Mu Xinyi X Wen Jia J Chen Qian Q Wang Zhengpin Z Wang Yijing Y Guo Meng M Yang Yi Y Xu JinRui J Wei Zhiqing Z Xia Guoliang G Yang Mengye M Wang Chao C
Biology open 20181112 11
Lanosterol 14 α-demethylase (CYP51) plays a crucial role in cholesterol biosynthesis. In gamete development, CYP51 is involved in initiating meiosis resumption in oocytes through its product, meiosis activating sterol (MAS). In this study, CYP51 was observed to localize within the nucleus of germ cells undergoing meiotic prophase I. Following the addition of retinoic acid (RA) to induce meiosis or the RA receptor pan-antagonist AGN193109 to block meiosis in fetal ovaries, the translocation of CY ...[more]