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In Vitro Anticancer and Proapoptotic Activities of Steroidal Glycosides from the Starfish Anthenea aspera.

ABSTRACT: New marine glycoconjugates-the steroidal glycosides designated as anthenosides V?X (1?3)-and the seven previously known anthenosides E (4), G (5), J (6), K (7), S1 (8), S4 (9), and S6 (10) were isolated from the extract of the tropical starfish Anthenea aspera. The structures of 1?3 were elucidated by extensive NMR and ESIMS techniques. Glycoside 1 contains a rare 5?-cholest-8(14)-ene-3?,7?,16?-hydroxysteroidal nucleus. Compounds 2 and 3 were isolated as inseparable mixtures of epimers. All investigated compounds (1?10) at nontoxic concentrations inhibited colony formation of human melanoma RPMI-7951, breast cancer T-47D, and colorectal carcinoma HT-29 cells to a variable degree. The mixture of 6 and 7 possessed significant anticancer activity and induced apoptosis of HT-29 cells. The molecular mechanism of the proapoptotic action of this mixture was shown to be associated with the regulation of anti- and proapoptotic protein expression followed by the activation of initiator and effector caspases.

SUBMITTER: Malyarenko TV 

PROVIDER: S-EPMC6266882 | biostudies-other | 2018 Nov

REPOSITORIES: biostudies-other

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In Vitro Anticancer and Proapoptotic Activities of Steroidal Glycosides from the Starfish <i>Anthenea aspera</i>.

Malyarenko Timofey V TV   Malyarenko Olesya S OS   Kicha Alla A AA   Ivanchina Natalia V NV   Kalinovsky Anatoly I AI   Dmitrenok Pavel S PS   Ermakova Svetlana P SP   Stonik Valentin A VA  

Marine drugs 20181101 11

New marine glycoconjugates-the steroidal glycosides designated as anthenosides V⁻X (<b>1</b>⁻<b>3</b>)-and the seven previously known anthenosides E (<b>4</b>), G (<b>5</b>), J (<b>6</b>), K (<b>7</b>), S1 (<b>8</b>), S4 (<b>9</b>), and S6 (<b>10</b>) were isolated from the extract of the tropical starfish <i>Anthenea aspera</i>. The structures of <b>1</b>⁻<b>3</b> were elucidated by extensive NMR and ESIMS techniques. Glycoside <b>1</b> contains a rare 5α-cholest-8(14)-ene-3α,7β,16α-hydroxyster  ...[more]

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